Articles

Global Burden of Early-Onset Cancers Attributable to Metabolic Risk Factors from 1990 to 2021 and Projections to 2040

Wenmei 1, Kaijian Zhou 2, Liang He 3, et al. Endocrinol Metab (Seoul). 2026 Jan 5

Early-onset cancers (diagnosed in individuals under 50 years of age) are increasingly contributing to the global cancer burden. Among the known contributors, specific metabolic risk factors-namely high body mass index (BMI) and high fasting plasma glucose (FPG)-have emerged as significant determinants. This study ... Read More

24 Mar, 2026

Disparities in the incidence, mortality and disability-adjusted life years of 33 early-onset cancer groups globally, 2012-2021: a systematic analysis

Wenxin Yan, Min Liu, Wenzhan Jing et al. Exp Hematol Oncol. 2025 Mar 17;14(1):38

The global cancer burden is rising, with early-onset cancers becoming more prevalent. We aimed to investigate the burden, trend and population disparity in 33 early-onset cancers from 2012 to 2021. In 2021, there were 2.65 million new early-onset cancer cases excluding non-melanoma skin cancer (NMSC), resulti... Read More

24 Mar, 2026

Global Epidemiologic Trends of Early-Onset Cancers From 1990 to 2021 and Projection to 2040

Rupayan Kundu, Ankush Mukhopadhyay, Niladri Kal, et al .JCO Glob Oncol 12, e2500170(2026). Volume 12

Early-onset cancer (EOC), defined as cancer occurring in individuals age 15-49 years, represents a growing global health burden.  In 2021, there were approximately 23.6 million new EOC cases and 0.99 million deaths globally. The highest incidence rates were observed in breast, nonmelanoma skin, and cervical c... Read More

24 Mar, 2026

PreveCan, an app for cancer prevention based on the 2018 WCRF/AICR guidelines: development and usability

Emma Ruiz-Moreno, Javier García-Péreza,Virginia Lope. Gaceta Sanitaria 40 (2026) 102565

PreveCan is a useful tool to inform Spanish-speaking users on lifestyle changes to reduce cancer risk by assessing adherence to WCRF/AICR cancer prevention guidelines. The app was developed using a user-centred design approach involving epidemiology, medical, nutrition and software design experts and public. PreveCan e... Read More

24 Mar, 2026

Association between risk-reducing surgeries and survival in young BRCA carriers with breast cancer: an international cohort study

Eva Blondeaux1, Amir Sonnenblick, Elisa Agostinetto et al. Lancet Oncol. 2025 26(6):759-770

We investigated the association between risk-reducing mastectomy (RRM) or risk-reducing salpingo-oophorectomy (RRSO), or both procedures, with survival outcomes in a large global cohort of young BRCA carriers with previous breast cancer.  Between Jan 1, 2000, and Dec 31, 2020, 5290 patients were included, of whom ... Read More

24 Mar, 2026

Scenarios on years of life lost and life expectancy from 2022 to 2050: a systematic analysis for the Global Burden of Disease Study 2021

GBD 2021 Tobacco Forecasting Collaborators Lancet Public Health. 2024 Oct;9(10):e729-e744

Smoking is the leading behavioral risk factor for mortality globally, accounting for more than 175 million deaths and nearly 4·30 billion years of life lost (YLLs) from 1990 to 2021. The pace of decline in smoking prevalence has slowed in recent years for many countries, and although strategies have recently been p... Read More

24 Mar, 2026

The indirect costs of vaccine-preventable cancer mortality in the Middle East and North Africa (MENA)

Goran Bencinaa, Dzhumber Ugrekhelidzeb, Hayley Shoelc. Journal Of Medical Economics 2024, Vol. 27, NO. S2, 41–50

Infections are responsible for 13% of cancer cases worldwide, with human papillomavirus (HPV) and hepatitis B (HBV) among the infections associated with cancer for which vaccines are available. The aim of this study was to estimate the indirect cost of premature mortality related to cancers caused by HPV and HBV in... Read More

24 Mar, 2026

Proportion and number of cancer cases and deaths attributable to potentially modifiable risk factors in the United States

Farhad Islami MD, Emily C. Marlow, Blake Thomson, et al. CA Cancer J Clin. 2024;74:405–432

The authors estimated the proportion and number of invasive cancer cases (excluding nonmelanoma skin cancers) and deaths, overall and for 30 cancer types among adults who were aged 30 years and older in 2019 in the United States, that were attributable to potentially modifiable risk factors. These included cigarett... Read More

24 Mar, 2026

Global and regional cancer burden attributable to modifiable risk factors to inform prevention

Hanna Fink, Oliver Langselius, Jérôme Vignat, Harriet Rumgay, et al. Nature Medicine. Published online: 03 February 2026

We estimated the 2022 global and national cancer burden attributable to 30 such factors, including tobacco smoking, alcohol consumption, high body mass index, insufficient physical activity, smokeless tobacco and areca nut, suboptimal breastfeeding, air pollution, ultraviolet radiation, 9 infectious agents and 13 o... Read More

24 Mar, 2026

Estimation of Cancer Deaths Averted from Prevention, Screening, and Treatment Efforts, 1975-2020

Katrina A. B. Goddard; Eric J. Feuer; Jeanne S. Mandelblatt; et al. JAMA Oncol. 2025;11(2):162-167.

The contributions of different interventions across the cancer control continuum was evaluated with primary prevention via smoking reduction (lung), screening for interception (cervix and colorectal) or early detection (breast, cervix, colorectal, and prostate), and therapy (breast, colorectal, lung, and prostate).... Read More

24 Mar, 2026